Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Molybdenum ion transfer onto molybdopterin

MPT + MoO4(2-) + ATP + H2O → MoCo + AMP + PPi

Reactome: R-HSA-947531
Compartment: cytosol · plasma membrane
Rhea: None recorded

Inputs

MPTCHEBI:58698, C10H11N5O6PS2, cytosol
MoO4(2-)CHEBI:36264, MoO4, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

MoCoCHEBI:25372, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol

Catalysed by

molybdopterin molybdotransferase activity of 3xGPHN:3xMg2+ [plasma membrane]EC 2.10.1.1

Literature

The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells Proc Natl Acad Sci U S A, 1999