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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3

L-Cys + MOCS3:Zn2+ (red.) → L-Ala + MOCS3-S-S(1-):Zn2+

Reactome: R-HSA-947514
Compartment: cytosol
Rhea: None recorded

Inputs

L-CysCHEBI:35235, C3H7NO2S, cytosol
MOCS3:Zn2+ (red.)R-HSA-947543, cytosol

Outputs

L-AlaCHEBI:57972, C3H7NO2, cytosol
MOCS3-S-S(1-):Zn2+R-HSA-947584, cytosol

Catalysed by

cysteine desulfurase activity of PXLP-K198-NFS1-2 dimer [cytosol]EC 2.8.1.7

Literature

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis J Biol Chem, 2008