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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Exchange of oxygen with sulfur in MoCo

L-Cys + MoCo → L-Ala + sulfurated MoCo

Reactome: R-HSA-947499
Compartment: cytosol
Rhea: None recorded

Inputs

L-CysCHEBI:35235, C3H7NO2S, cytosol
MoCoCHEBI:25372, cytosol

Outputs

L-AlaCHEBI:57972, C3H7NO2, cytosol
sulfurated MoCoCHEBI:60102, C10H11MoN5O8PS3, cytosol

Catalysed by

molybdenum cofactor sulfurtransferase activity of PXLP-K264-MOCOS [cytosol]EC 2.8.1.9; UniProt Q96EN8

Literature

Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II Biochem Biophys Res Commun, 2001