ABCG2 tetramer transports heme from cytosol to extracellular region
ferroheme + ATP + H2O → heme + ADP + Pi + H+
- Reactome
- R-HSA-917979
- Compartment
- plasma membrane
- Rhea
- RHEA:19261
Inputs
- ferrohemeCHEBI:60344, C34H30FeN4O4, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- hemeCHEBI:60344, C34H30FeN4O4, extracellular region
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- PiCHEBI:43474, HO4P, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- ABC-type heme transporter activity of ABCG2 tetramer [plasma membrane]EC 7.6.2.5
Literature
- Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2 J. Biol. Chem., 2004
- The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme J Biol Chem, 2004
- Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) Oncogene, 2003
- The expression and functional characterization of ABCG2 in brain endothelial cells and vessels FASEB J, 2003