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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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FLVCR1-1 transports heme from cytosol to extracellular region

ferroheme → heme

Reactome
R-HSA-917892
Compartment
plasma membrane
Rhea
RHEA:75443

Inputs

Outputs

Catalysed by

  • heme transmembrane transporter activity of FLVCR1-1 [plasma membrane]UniProt Q9Y5Y0

Literature

  1. Identification of a human heme exporter that is essential for erythropoiesis Cell, 2004
  2. Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis Haematologica, 2008