5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA
5-HEPE + NADP+ → 5-oxo-EPA + NADPH + H+
- Reactome
- R-HSA-9027632
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- None recorded
Inputs
- 5-HEPECHEBI:90737, C20H29O3, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- 5-oxo-EPACHEBI:140337, C20H27O3, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of 5-HEDH [endoplasmic reticulum membrane]EC 1.1.1
Literature
- Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils J. Lipid Res., 1995
- Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives PLoS ONE, 2014
- Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids J. Pharmacol. Exp. Ther., 2009