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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA

7-HDHA + NADP+ → 7-oxo-DHA + NADPH + H+

Reactome: R-HSA-9027631
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

7-HDHACHEBI:140373, C22H31O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

7-oxo-DHACHEBI:140382, C22H29O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of 5-HEDH [endoplasmic reticulum membrane]EC 1.1.1

Literature

Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives PLoS ONE, 2014
Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids J. Pharmacol. Exp. Ther., 2009