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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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ALOX5 oxidises EPA to 5-HEPE

EPA + O2 → 5-HEPE

Reactome
R-HSA-9027628
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]EC 1.13; UniProt P09917

Literature

  1. Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives PLoS ONE, 2014
  2. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils J. Lipid Res., 1995