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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3

7-HDPAn-3 + NADP+ → 7-oxo-DPAn-3 + NADPH + H+

Reactome: R-HSA-9027625
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

7-HDPAn-3CHEBI:140375, C22H33O3, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

7-oxo-DPAn-3CHEBI:140386, C22H31O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of 5-HEDH [endoplasmic reticulum membrane]EC 1.1.1

Literature

Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives PLoS ONE, 2014
Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids J. Pharmacol. Exp. Ther., 2009