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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3

O2 + DPAn-3 → 17-HDPAn-3

Reactome
R-HSA-9027607
Compartment
cytosol · endoplasmic reticulum membrane
Rhea
RHEA:50833

Inputs

Outputs

Catalysed by

  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]EC 1.13

Literature

  1. Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids Nat. Chem. Biol., 2010
  2. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals J. Exp. Med., 2002