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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PTGS2 dimer oxidises DHA to 13-HDHA

DHA + O2 + hydrogen donor → 13-HDHA + hydrogen acceptor

Reactome: R-HSA-9027532
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:48821

Inputs

DHACHEBI:77016, C22H31O2, cytosol
O2CHEBI:15379, O2, cytosol
hydrogen donorCHEBI:17499, H2A, cytosol

Outputs

13-HDHACHEBI:90815, C22H31O3, cytosol
hydrogen acceptorCHEBI:13193, A, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of PTGS2 dimer [endoplasmic reticulum membrane]EC 1.13

Literature

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals J. Exp. Med., 2002
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids Nat. Chem. Biol., 2010