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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA

14(R)-HDHA + NADPH + O2 + H+ → 14(R),21(S/R)-diHDHA + NADP+ + H2O

Reactome: R-HSA-9027321
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

14(R)-HDHACHEBI:136525, C22H31O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol
H+CHEBI:15378, H, cytosol

Outputs

14(R),21(S/R)-diHDHAR-ALL-9027324, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

monooxygenase activity of CYP2E1 [endoplasmic reticulum membrane]UniProt P05181

Literature

Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing J. Lipid Res., 2010