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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYPs hydroxylate DHA to 14(R)-HDHA

DHA + H+ + NADPH + O2 → 14(R)-HDHA + H2O + NADP+

Reactome: R-HSA-9027043
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

DHACHEBI:77016, C22H31O2, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

14(R)-HDHACHEBI:136525, C22H31O3, cytosol
H2OCHEBI:15377, H2O, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP1A2,2C8,2C9,2D6,2E1,3A4 [endoplasmic reticulum membrane]

Literature

Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages Chem. Biol., 2014