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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1

13(S),14(S)-epoxy-DHA + GSH → MCTR1

Reactome: R-HSA-9026780
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:53509

Inputs

13(S),14(S)-epoxy-DHACHEBI:131958, C22H29O3, cytosol
GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

MCTR1CHEBI:137407, C32H45N3O9S, cytosol

Catalysed by

glutathione transferase activity of LTC4S trimer [endoplasmic reticulum membrane]EC 2.5.1.18

Literature

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A., 2016
Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Proc. Natl. Acad. Sci. U.S.A., 2014
Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3 PLoS ONE, 2016