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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GGT hydrolyses MCTR1 to MCTR2

MCTR1 + H2O → MCTR2 + L-Glu

Reactome: R-HSA-9026757
Compartment: cytosol
Rhea: RHEA:53513

Inputs

MCTR1CHEBI:137407, C32H45N3O9S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

MCTR2CHEBI:137408, C27H39N2O6S, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol

Catalysed by

glutathione gamma-glutamate hydrolase activity of GGT [cytosol]EC 3.4.19.13

Literature

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Proc. Natl. Acad. Sci. U.S.A., 2014
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A., 2016
Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3 PLoS ONE, 2016