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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3

14(S)-Hp-DHA + NADP+ → 13,14(S)-epoxy-DPAn-3 + NADPH

Reactome: R-HSA-9026007
Compartment: cytosol
Rhea: None recorded

Inputs

14(S)-Hp-DHACHEBI:140279, C22H31O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

13,14(S)-epoxy-DPAn-3CHEBI:140235, C22H31O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Catalysed by

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]EC 1.13.11.31

Literature

Novel n-3 immunoresolvents: structures and actions Sci Rep, 2013