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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3

DPAn-3 + O2 → 17(S)-Hp-DPAn-3

Reactome: R-HSA-9026003
Compartment: cytosol
Rhea: None recorded

Inputs

DPAn-3CHEBI:77224, C22H33O2, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

17(S)-Hp-DPAn-3CHEBI:140291, C22H33O4, cytosol

Catalysed by

arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]EC 1.13.11.33; UniProt P16050

Literature

Novel n-3 immunoresolvents: structures and actions Sci Rep, 2013
Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA Org. Biomol. Chem., 2017
Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions J. Nat. Prod., 2014