Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA

16(S),17(S)-epoxy-DPAn-3 + H2O → PD1n-3DPA,PD2n-3DPA

Reactome: R-HSA-9026000
Compartment: cytosol
Rhea: None recorded

Inputs

16(S),17(S)-epoxy-DPAn-3CHEBI:140290, C22H31O3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

PD1n-3DPA,PD2n-3DPAR-ALL-9026023, cytosol

Catalysed by

epoxide hydrolase activity of Epoxide hydrolase [cytosol]EC 3.3.2.10

Literature

Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA Org. Biomol. Chem., 2017
Novel n-3 immunoresolvents: structures and actions Sci Rep, 2013
Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions J. Nat. Prod., 2014