ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3
17(S)-Hp-DPAn-3 + NADP+ → 16(S),17(S)-epoxy-DPAn-3 + NADPH
- Reactome
- R-HSA-9025999
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 17(S)-Hp-DPAn-3CHEBI:140291, C22H33O4, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- 16(S),17(S)-epoxy-DPAn-3CHEBI:140290, C22H31O3, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
Catalysed by
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]EC 1.13; UniProt P09917
Literature
- Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA Org. Biomol. Chem., 2017
- Novel n-3 immunoresolvents: structures and actions Sci Rep, 2013
- Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions J. Nat. Prod., 2014