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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6

O2 + DPAn-6 → 14(S)-HDPAn-6

Reactome: R-HSA-9025957
Compartment: cytosol
Rhea: None recorded

Inputs

O2CHEBI:15379, O2, cytosol
DPAn-6CHEBI:77226, C22H33O2, cytosol

Outputs

14(S)-HDPAn-6CHEBI:140251, C22H33O3, cytosol

Catalysed by

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]EC 1.13.11.31

Literature

Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6) J. Biol. Chem., 2009
Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6) Biochem. Pharmacol., 2010
Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase J. Lipid Res., 2013