ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6
O2 + DPAn-6 → 17(S)-HDPAn-6, 10(S),17(S)-diHDPAn-6
- Reactome
- R-HSA-9025152
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- O2CHEBI:15379, O2, cytosol
- DPAn-6CHEBI:77226, C22H33O2, cytosol
Outputs
- 17(S)-HDPAn-6, 10(S),17(S)-diHDPAn-6R-ALL-9025151, cytosol
Catalysed by
- arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]EC 1.13.11.33; UniProt P16050
Literature
- Biogenic synthesis, purification, and chemical characterization of anti-inflammatory resolvins derived from docosapentaenoic acid (DPAn-6) J. Biol. Chem., 2009
- Metabolism and biological production of resolvins derived from docosapentaenoic acid (DPAn-6) Biochem. Pharmacol., 2010
- Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo Lipids, 2010
- Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase J. Lipid Res., 2013
- Total synthesis of neuroprotectin D1 analogues derived from omega-6 docosapentaenoic acid (DPA) and adrenic acid (AdA) from a common pivotal, late-stage intermediate J. Org. Chem., 2014