Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1
13(S),14(S)-epoxy-DHA + H2O → MaR1
- Reactome
- R-HSA-9024973
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 13(S),14(S)-epoxy-DHACHEBI:131958, C22H29O3, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- MaR1CHEBI:138249, C22H32O4, cytosol
Catalysed by
- epoxide hydrolase activity of Epoxide hydrolase [cytosol]EC 3.3.2.10
Literature
- The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype FASEB J., 2013
- Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions J. Exp. Med., 2009
- The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells PLoS ONE, 2014
- Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain FASEB J., 2012
- Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages PLoS ONE, 2014