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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1

13(S),14(S)-epoxy-DHA + H2O → MaR1

Reactome
R-HSA-9024973
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • epoxide hydrolase activity of Epoxide hydrolase [cytosol]EC 3.3.2.10

Literature

  1. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype FASEB J., 2013
  2. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions J. Exp. Med., 2009
  3. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells PLoS ONE, 2014
  4. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain FASEB J., 2012
  5. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages PLoS ONE, 2014