ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA
17(S)-Hp-DHA + NADP+ → 16S,17S-epoxy-DHA + NADPH
- Reactome
- R-HSA-9024881
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 17(S)-Hp-DHACHEBI:133795, C22H31O4, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
Outputs
- 16S,17S-epoxy-DHACHEBI:140313, C22H29O3, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
Catalysed by
- arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]EC 1.13.11.33; UniProt P16050
Literature
- Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages J. Nat. Prod., 2015
- Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation J. Biol. Chem., 2003
- Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms J. Am. Soc. Mass Spectrom., 2007
- The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation Am. J. Pathol., 2016
- Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes J. Immunol., 2006