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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1

RvD1 + NAD+ → 17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1 + NADH + H+

Reactome: R-HSA-9024766
Compartment: cytosol
Rhea: RHEA:50129, RHEA:50125

Inputs

RvD1CHEBI:132079, C22H31O5, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

17(S)-oxo-RvD1, 8-oxo-17(S)-RvD1R-ALL-9024799, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]EC 1.1.1.141

Literature

Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation J. Biol. Chem., 2007