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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA

4(S)-Hp-17(R)-HDHA + NADP+ → 4S(5)-epoxy-17(R)-HDHA + NADPH

Reactome: R-HSA-9020278
Compartment: cytosol
Rhea: None recorded

Inputs

4(S)-Hp-17(R)-HDHACHEBI:747573, C22H31O5, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

4S(5)-epoxy-17(R)-HDHACHEBI:747575, C22H29O4, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]EC 1.13; UniProt P09917

Literature

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals J. Exp. Med., 2002