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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA

17(S)-Hp-DHA + 2 GSH → 17(S)-HDHA + GSSG + H2O

Reactome: R-HSA-9020273
Compartment: cytosol
Rhea: RHEA:76716

Inputs

17(S)-Hp-DHACHEBI:133795, C22H31O4, cytosol
2 GSHCHEBI:57925, C10H16N3O6S, cytosol

Outputs

17(S)-HDHACHEBI:195403, C22H31O3, cytosol
GSSGCHEBI:58297, C20H30N6O12S2, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]EC 1.11.1.12; UniProt P36969

Literature

Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase IUBMB Life, 2013
Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury Biochem. Biophys. Res. Commun., 1996