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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA

17(R)-Hp-DHA + NADP+ → 17R(16)-epoxy-DHA + NADPH

Reactome: R-HSA-9020262
Compartment: cytosol
Rhea: None recorded

Inputs

17(R)-Hp-DHACHEBI:747572, C22H31O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

17R(16)-epoxy-DHACHEBI:140346, C22H29O3, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Catalysed by

arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]EC 1.13.11.33; UniProt P16050

Literature

Novel proresolving aspirin-triggered DHA pathway Chem. Biol., 2011