LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2
7S(8)-epoxy-17(S)-HDHA + H2O → RvD1, RvD2
- Reactome
- R-HSA-9020258
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- 7S(8)-epoxy-17(S)-HDHACHEBI:747581, C22H29O4, cytosol
- H2OCHEBI:15377, H2O, cytosol
Outputs
- RvD1, RvD2R-ALL-9024759, cytosol
Catalysed by
- epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]EC 3.3.2.10
Literature
- Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis Nature, 2009
- Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation J. Biol. Chem., 2007
- Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals J. Exp. Med., 2002