Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4

4S(5)-epoxy-17(S)-HDHA + H2O → RvD3, RvD4

Reactome: R-HSA-9020253
Compartment: cytosol
Rhea: None recorded

Inputs

4S(5)-epoxy-17(S)-HDHACHEBI:747582, C22H29O4, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

RvD3, RvD4R-ALL-9024809, cytosol

Catalysed by

epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]EC 3.3.2.10

Literature

Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents Chem. Biol., 2013
Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA Org. Biomol. Chem., 2017
Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance Sci Rep, 2016