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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

5-HEDH dehydrogenates 5(S)-Hp-18(R)-HEPE to 18(R)-RvE2

5(S)-Hp-18(R)-HEPE + hydrogen donor → 18(R)-RvE2 + hydrogen acceptor + H2O

Reactome: R-HSA-9018901
Compartment: cytosol
Rhea: RHEA:52021

Inputs

5(S)-Hp-18(R)-HEPECHEBI:132218, C20H29O5, cytosol
hydrogen donorCHEBI:17499, H2A, cytosol

Outputs

18(R)-RvE2CHEBI:133368, C20H29O4, cytosol
hydrogen acceptorCHEBI:13193, A, cytosol
H2OCHEBI:15377, H2O, cytosol

Catalysed by

NADPH dehydrogenase activity of 5-HEDH [cytosol]EC 1.6.99.1

Literature

Resolvin E2 formation and impact in inflammation resolution J. Immunol., 2012
Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Chem. Biol., 2006
Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids J. Pharmacol. Exp. Ther., 2009