Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE

EPA + O2 → 18(S)-HpEPE, 18(R)-HpEPE

Reactome: R-HSA-9018880
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

EPACHEBI:58562, C20H29O2, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

18(S)-HpEPE, 18(R)-HpEPER-ALL-9022921, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]EC 1.13.11

Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE

Inputs

Outputs

Catalysed by

Literature