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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CYP monooxygenates EPA to 18(S)-HpEPE

EPA + NADPH + O2 + H+ → 18(S)-HpEPE + NADP+

Reactome: R-HSA-9018874
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

EPACHEBI:58562, C20H29O2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
O2CHEBI:15379, O2, cytosol
H+CHEBI:15378, H, cytosol

Outputs

18(S)-HpEPECHEBI:747601, C20H29O4, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

monooxygenase activity of CYP [endoplasmic reticulum membrane]

Literature

Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids J. Biol. Chem., 2010