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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE

5(S)-Hp-18(S)-HEPE + O2 → 5S,6S-epoxy-18(S)-HEPE

Reactome
R-HSA-9018859
Compartment
cytosol
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of ALOX5 [cytosol]EC 1.13; UniProt P09917

Literature

  1. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis Chem. Biol., 2006
  2. Resolvin E2 formation and impact in inflammation resolution J. Immunol., 2012