Skip to content
DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
Data
100%

Loading the map…

SAMD8 transfers phosphatidyl from PE onto C16DH CER

PE + C16DH CER → CPE + DAG

Reactome
R-HSA-8959462
Compartment
endoplasmic reticulum membrane · endoplasmic reticulum lumen
Rhea
RHEA:42128

Inputs

  • PECHEBI:64612, C7H12NO8PR2, endoplasmic reticulum lumen
  • C16DH CERCHEBI:67042, C34H69NO3, endoplasmic reticulum lumen

Outputs

  • CPECHEBI:78654, C36H75N2O6P, endoplasmic reticulum lumen
  • DAGCHEBI:17815, C5H6O5R2, endoplasmic reticulum membrane

Catalysed by

  • ceramide phosphoethanolamine synthase activity of SAMD8 trimer [endoplasmic reticulum membrane]EC 2.7.8.48

Literature

  1. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER J. Cell Biol., 2009
  2. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid Biochim Biophys Acta Biomembr, 2019
  3. ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain Sci Rep, 2017