Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NADK2 dimer phosphorylates NAD+ to NADP+

NAD+ + ATP → NADP+ + ADP + H+

Reactome: R-HSA-8955030
Compartment: mitochondrial matrix
Rhea: RHEA:18630

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

NAD+ kinase activity of NADK2 dimer [mitochondrial matrix]EC 2.7.1.23

Literature

Identification and characterization of a human mitochondrial NAD kinase Nat Commun, 2012
Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia Hum. Mol. Genet., 2014