Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NT5E:Zn2+ hydrolyses NAD+

H2O + NAD+ → NMN + Pi + AMP + 2 H+

Reactome: R-HSA-8940070
Compartment: extracellular region · plasma membrane
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, extracellular region
NAD+CHEBI:57540, C21H26N7O14P2, extracellular region

Outputs

NMNCHEBI:14649, C11H14N2O8P, extracellular region
PiCHEBI:43474, HO4P, extracellular region
AMPCHEBI:456215, C10H12N5O7P, extracellular region
2 H+CHEBI:15378, H, extracellular region

Catalysed by

5'-nucleotidase activity of NT5E:Zn2+ dimer [plasma membrane]EC 3.1.3.5

NT5E:Zn2+ hydrolyses NAD+

Inputs

Outputs

Catalysed by

Literature