NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+
NMN + ATP + H+ → NAD+ + PPi
- Reactome
- R-HSA-8939959
- Compartment
- cytosol · Golgi membrane
- Rhea
- RHEA:21361
Inputs
- NMNCHEBI:14649, C11H14N2O8P, cytosol
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- H+CHEBI:15378, H, cytosol
Outputs
- NAD+CHEBI:57540, C21H26N7O14P2, cytosol
- PPiCHEBI:33019, HO7P2, cytosol
Catalysed by
- nicotinamide-nucleotide adenylyltransferase activity of NMNAT2:Mg2+ [Golgi membrane]EC 2.7.7.1
Literature
- Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms J Biol Chem, 2005
- Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases J Biol Chem, 2010
- Identification of a novel human nicotinamide mononucleotide adenylyltransferase Biochem Biophys Res Commun, 2002
- Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis Biochemistry, 2007
- Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas Biochem J, 2004