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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ENPPs hydrolyse CoA-SH to PPANT, PAP

CoA-SH + H2O → PPANT + PAP

Reactome: R-HSA-8938314
Compartment: extracellular region · plasma membrane
Rhea: RHEA:64989

Inputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

PPANTCHEBI:61723, C11H21N2O7PS, extracellular region
PAPCHEBI:58343, C10H11N5O10P2, extracellular region

Catalysed by

hydrolase activity of 2xENPP1, 2xENPP2, 2xENPP3 [plasma membrane]EC 3

Literature

Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family Biochim. Biophys. Acta, 2003