CD38 hydrolyses NAD+ to NAM and ADP-ribose
NAD+ + H2O → NAM + ADP-ribose + H+
- Reactome
- R-HSA-8938076
- Compartment
- extracellular region · plasma membrane
- Rhea
- RHEA:16302
Inputs
- NAD+CHEBI:57540, C21H26N7O14P2, extracellular region
- H2OCHEBI:15377, H2O, extracellular region
Outputs
- NAMCHEBI:17154, C6H6N2O, extracellular region
- ADP-riboseCHEBI:57967, C15H21N5O14P2, extracellular region
- H+CHEBI:15378, H, extracellular region
Catalysed by
- NAD+ nucleosidase activity, cyclic ADP-ribose generating of CD38 [plasma membrane]EC 3.2.2.6; UniProt P28907
Literature
- NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases Biochem. Biophys. Res. Commun., 2006
- Cyclic ADP-ribose and its metabolic enzymes Biochimie, 1995
- Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes Mol. Cell. Biochem., 1999
- Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization J. Biol. Chem., 2012