Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)

3 NAD+ + acceptor protein → 3 NAM + ADP-D-ribosyl-acceptor protein

Reactome: R-HSA-8938073
Compartment: cytosol
Rhea: RHEA:58225

Inputs

3 NAD+CHEBI:57540, C21H26N7O14P2, cytosol
acceptor proteinR-HSA-9938200, cytosol

Outputs

3 NAMCHEBI:17154, C6H6N2O, cytosol
ADP-D-ribosyl-acceptor proteinR-HSA-9938174, cytosol

Catalysed by

NAD+ poly-ADP-ribosyltransferase activity of PARPs [cytosol]EC 2.4.2.30

PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)

Inputs

Outputs

Catalysed by

Literature