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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Formation of 4Fe-4S cluster on ISCA1:ISCA2

2 GLRX5:2Fe-2S + ISCA1:ISCA2 → ISCA1:ISCA2:4Fe-4S + 2 GLRX5

Reactome: R-HSA-8878815
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

2 GLRX5:2Fe-2SR-HSA-8878793, mitochondrial matrix
ISCA1:ISCA2R-HSA-8878840, mitochondrial matrix

Outputs

ISCA1:ISCA2:4Fe-4SR-HSA-8878796, mitochondrial matrix
2 GLRX5R-HSA-2564761, mitochondrial matrix

Catalysed by

iron-sulfur transferase activity of ISCA1:ISCA2 [mitochondrial matrix]

Literature

Formation of [4Fe-4S] clusters in the mitochondrial iron-sulfur cluster assembly machinery J. Am. Chem. Soc., 2014
The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation Mol. Biol. Cell, 2012
[2Fe-2S] cluster transfer in iron-sulfur protein biogenesis Proc. Natl. Acad. Sci. U.S.A., 2014
Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis Hum. Mol. Genet., 2010
Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins J. Biol. Chem., 2011
[4Fe-4S] Cluster Assembly in Mitochondria and Its Impairment by Copper J. Am. Chem. Soc., 2017