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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC25A19 transports ThDP from cytosol to mitochondrial matrix

ThDP → ThDP

Reactome: R-HSA-8875838
Compartment: mitochondrial intermembrane space · mitochondrial inner membrane · mitochondrial matrix
Rhea: RHEA:75471

Inputs

ThDPCHEBI:58937, C12H16N4O7P2S, cytosol

Outputs

ThDPCHEBI:58937, C12H16N4O7P2S, mitochondrial matrix

Catalysed by

thiamine pyrophosphate transmembrane transporter activity of SLC25A19 [mitochondrial inner membrane]UniProt Q9HC21

Literature

The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier Mitochondrion, 2008
Amish microcephaly: Long-term survival and biochemical characterization Am. J. Med. Genet. A, 2010