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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose

NAD+ + H2O → NAM + ADP-ribose + H+

Reactome: R-HSA-8870346
Compartment: extracellular region · plasma membrane
Rhea: RHEA:16302

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

NAMCHEBI:17154, C6H6N2O, extracellular region
ADP-riboseCHEBI:57967, C15H21N5O14P2, extracellular region
H+CHEBI:15378, H, extracellular region

Catalysed by

NAD+ nucleosidase activity, cyclic ADP-ribose generating of BST1 dimer [plasma membrane]EC 3.2.2.6

Literature

Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities J. Mol. Biol., 2002