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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NMRK1 phosphorylates NR to yield NMN

NR + ATP → NMN + ADP + H+

Reactome: R-HSA-8869633
Compartment: cytosol
Rhea: RHEA:14018

Inputs

NRCHEBI:15927, C11H15N2O5, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

NMNCHEBI:14649, C11H14N2O8P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

ribosylnicotinamide kinase activity of NMRK1 [cytosol]EC 2.7.1.22; UniProt Q9NWW6

Literature

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans Cell, 2004
NAD + metabolism and its roles in cellular processes during ageing Nat Rev Mol Cell Biol, 2021
Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation J. Biol. Chem., 2011
Purification and properties of a human nicotinamide ribonucleoside kinase Arch. Biochem. Biophys., 1996
The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis J. Biol. Chem., 2009
Nicotinamide riboside kinase structures reveal new pathways to NAD+ PLoS Biol., 2007