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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MANBA hydrolyses GlcNAc:Man

GlcNAc:Man → Man + GlcNAc

Reactome: R-HSA-8853710
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

GlcNAc:ManCHEBI:71553, C14H25NO11, lysosomal lumen

Outputs

ManCHEBI:4208, C6H12O6, lysosomal lumen
GlcNAcCHEBI:17411, C8H15NO6, lysosomal lumen

Catalysed by

beta-mannosidase activity of MANBA [lysosomal lumen]EC 3.2.1.25; UniProt O00462

Literature

Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis Hum. Mol. Genet., 1998
Mammalian beta-D-mannosidase and beta-mannosidosis Biochimie, 1992
Angiokeratoma corporis diffusum in human beta-mannosidosis: Report of a new case and a novel mutation J. Am. Acad. Dermatol., 2007