SLC35B2,3 exchange cytosolic PAPS with Golgi PAP
PAPS + PAP → PAPS + PAP
- Reactome
- R-HSA-741449
- Compartment
- Golgi membrane · Golgi lumen · cytosol
- Rhea
- RHEA:76065, RHEA:76063
Inputs
- PAPSCHEBI:58339, C10H11N5O13P2S, cytosol
- PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
Outputs
- PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
- PAPCHEBI:58343, C10H11N5O10P2, cytosol
Catalysed by
- 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity of SLC35B2,3 [Golgi membrane]
Literature
- Identification and partial purification of PAPS translocase Biochemistry, 1996
- Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter J Biol Chem, 2003
- Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2 J Biol Chem, 2006
- Biallelic variants in SLC35B2 cause a novel chondrodysplasia with hypomyelinating leukodystrophy Brain, 2022