glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP
PYGL dimer b form + 2 ATP → PYGL dimer a form + 2 ADP + 2 H+
- Reactome
- R-HSA-71588
- Compartment
- cytosol
- Rhea
- RHEA:17990
Inputs
- PYGL dimer b formR-HSA-71581, cytosol
- 2 ATPCHEBI:30616, C10H12N5O13P3, cytosol
Outputs
- PYGL dimer a formR-HSA-71586, cytosol
- 2 ADPCHEBI:456216, C10H12N5O10P2, cytosol
- 2 H+CHEBI:15378, H, cytosol
Catalysed by
- phosphorylase kinase activity of phosphorylase kinase complex (PHKL) [cytosol]EC 2.7.11.19
Literature
- Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure Front Biosci, 1999
- Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases Eur J Hum Genet, 2003
- Correlation between subunit interactions and enzymatic activity of phosphorylase a. Method for determining equilibrium constants from initial rate measurements Biochemistry, 1970
- Enzymic conversion of phosphorylase a to phosphorylase b Biochim Biophys Acta, 1953
- Severe phenotype of phosphorylase kinase-deficient liver glycogenosis with mutations in the PHKG2 gene Pediatr Res, 2003
- X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit. Am J Hum Genet, 1995