OGDH dimer decarboxylates 2-OG
2OG + H+ + Lipo-K110-DLST → CO2 + SuccinyllipoH2-K110-DLST
- Reactome
- R-HSA-71401
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:12189
Inputs
- 2OGCHEBI:16810, C5H4O5, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- Lipo-K110-DLSTR-HSA-69993, mitochondrial matrix
Outputs
- CO2CHEBI:16526, CO2, mitochondrial matrix
- SuccinyllipoH2-K110-DLSTR-HSA-9853502, mitochondrial matrix
Catalysed by
- oxoglutarate dehydrogenase (succinyl-transferring) activity of OGDH complex [mitochondrial matrix]EC 1.2.4.2
Literature
- Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM Biochem Biophys Res Commun, 2022
- The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate Free Radic Biol Med, 2017
- Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate J Biol Chem, 2014
- Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site Biochem J, 2014