SUCLG1/A2 cleaves succinyl-CoA
ADP + Pi + SUCC-CoA → ATP + SUCCA + CoA-SH
- Reactome
- R-HSA-70997
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:17663, RHEA:17662
Inputs
- ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
- PiCHEBI:43474, HO4P, mitochondrial matrix
- SUCC-CoACHEBI:57292, C25H35N7O19P3S, mitochondrial matrix
Outputs
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- SUCCACHEBI:30031, C4H4O4, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
Catalysed by
- succinate-CoA ligase (ADP-forming) activity of SUCLA2:SUCLG1 [mitochondrial matrix]EC 6.2.1.5
Literature
- Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion Am J Hum Genet, 2005
- Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia J Clin Invest, 2000
- Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes J Biol Chem, 1998
- Characterization of the ATP- and GTP-specific succinyl-CoA synthetases in pigeon. The enzymes incorporate the same alpha-subunit. J Biol Chem, 1998
- Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues J Biol Chem, 2004
- Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A Biochim Biophys Acta, 1954