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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SDH complex dehydrogenates succinate

SUCCA + CoQ → FUMA + CoQH2

Reactome: R-HSA-70994
Compartment: mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:13714

Inputs

SUCCACHEBI:30031, C4H4O4, mitochondrial matrix
CoQCHEBI:46245, C59H90O4, mitochondrial inner membrane

Outputs

FUMACHEBI:29806, C4H2O4, mitochondrial matrix
CoQH2CHEBI:64183, C59H92O4, mitochondrial inner membrane

Catalysed by

succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane]EC 1.3.5.1

Literature

Succinate dehydrogenase deficiency in human Cell Mol Life Sci, 2005
The inhibitory effects of itaconic acid in vitro and in vivo J Biol Chem, 1952
STUDIES ON SUCCINATE DEHYDROGENASE. I. SPECTRAL PROPERTIES OF THE PURIFIED ENZYME AND FORMATION OF ENZYME-COMPETITIVE INHIBITOR COMPLEXES Biochim Biophys Acta, 1964
Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels J Biol Chem, 2016
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation Cell Metab, 2016
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase Cancer Cell, 2005